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This could be explained by the molecular pathophysiology of the weight reducing effects of bupropion, which directly stimulates the hypothalamic POMC neurons that in turn release -MSH and -endorphin

Targeting macrophage polarization to modulate the immune response is an appealing therapeutic strategy for autoimmune diseases, cancer, chronic inflammation, and obesity

Endocrinology 142 : 51825189 Hollenga C et al

Nutrient customization differs substantially between the two treatments

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