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[1] [4] Mood changes including low mood, irritability, or anxiety can be associated with declining B12 levels, though these symptoms are non-specific and can have many causes

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Homocysteine can either be remethylated to methionine or metabolized to cysteine through a transsulfuration pathway requiring vitamin B 6

doi: 10.1016/j.euroneuro.2013.10.007 [DOI] [PubMed] [Google Scholar] 5.Panksepp J