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Moreover, Parkin knockdown suppresses mtDNA transcription and replication in proliferating cells, indicating that Parkin is directly involved in the control of mitobiogenesis [222]

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The current sate of knowledge has moved on in 30 odd years and yet B12 maintenance dose has since worsened

The phase 2 and phase 3 trials focused primarily on total body weight reduction

instead Nrf1 is primarily localized to the membrane of the endoplasmic reticulum and is released and translocates to the nucleus during endoplasmic reticulum stress [113]

doi: 10.3390/cells11203260