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This activation triggers a wide range of downstream effects, including enhanced glucose uptake, fatty acid oxidation, and mitochondrial biogenesis

10.1038/cddis.2017.21 107 WirthensohnG.GuderW

Mol Ther Methods Clin Dev

Many individuals with cognitive impairment experience emotional challenges, such as depression or irritability

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Although this is an objective change, it is usually not the difference between a patient being happy or not, with happiness being the real goal