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Upon binding of these small molecules to a certain E3 ligase, a conformational change occurs that facilitates the binding of the E3 ligase to the POI (via induction or stabilization of protein-protein interactions), thus culminating in poly-ubiquitination and consequent proteasomal degradation of the target protein 203

Therefore, elucidating the differences and interconnections in the metabolism of various brain cell types is essential for understanding their respective roles in brain function

This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of the Ninth Peoples Hospital, affiliated with Shanghai Jiao Tong University School of Medicine

conceived of the idea of the manuscript

Personalized neoantigen vaccines have shown efficacy in treating lung cancer [193, 194]

It is a known EU allergen