glutathione peroxidase cycle Pathways Regulatory Phenomena in the Glutathione

While human clinical trials remain limited, the breadth and consistency of preclinical evidence combined with extensive user reports provides substantial insight into this peptides therapeutic potential

Image: Berk DR, Bentley DD, Bayliss SJ, Lind A, Urban Z

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doi: 10.1210/jc.2014-4298

F., Hehenkamp W

Mechanistically, peroxynitrite has been shown to have 2 distinct mechanisms of action in its interaction with NOS: it can either uncouple the enzyme by oxidation of bound BH 4 or abolish enzymatic function by oxidative destruction of the NOS heme site, thus rendering an inactive enzyme, as opposed to one that is uncoupled 49,50