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AD is characterized by the accumulation and aggregation of misfolded proteins in brain, the sustained activation of the UPR mediated by the misfold proteins initiates or mediates neurodegeneration (Hoozemans et al., 2005)

Many moles: Image used with permission of Journal of the American Academy of Dermatology: J Am Acad Dermatol 2015;73:491-9

For severe curvature, plication can still be performed

Consistent with other studies in similar populations [37, 41], our finding confirmed that DAA treatment in decompensated individuals was less effective than in liver transplant recipients but still achieves SVR in a majority of cases

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