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In the course of evolution, nature has optimized several glutathione-utilizing enzymes as efficient tools for their detoxification [8]

Higher expression of S100A8 gene was also related to poor prognosis and chemotherapy resistance in de novo AML [89]

These investigations, along with others, have contributed to the development of the current hypothesis for CBR distribution, which states that CB1 is largely found in brain and nearby structures like the pituitary (51) and peripheral nervous tissues (52), while CB2 is largely found in the immunological and reproductive systems

Mild redness, swelling, or itching is commonespecially when starting a new peptidebut these symptoms usually resolve on their own

In fact, since the ratio GSH:GSSG is only 1:10 and considered that GSH oxidation is favored, GSSG quantification was considered a difficult procedure

Biochem Pharmacol 186:114486