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In simple terms, NAD+ supports energy production while glutathione protects the body from the oxidative consequences of that energy production

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The loss of topoisomerase II or its inhibition by fluoroquinolones results in accumulation of positively supercoiled mtDNA, followed by cessation of mitochondrial transcription and replication initiation, causing depletion of mtDNA copy number

Bezshapochniy SB, Loburets VV, Loburets AV, Dzhirov OR, Podovzhniy OG