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The EFSA recently revised their upper limit to 255mg per day for adults including pregnant and lactating women 10

Without explicit approval from the manufacturer, that final dose had to be discarded
The therapeutic efficacy of ozone therapy may be partly due the controlled and moderate oxidative stress produced by the reactions of ozone with several biological components

(2022) 8:e25071

They originate from the germinal epithelium of the seminiferous tubules and are characterized by a slow growth rate

The major source of ROS comes from non-enzymatic processes in the mitochondrial respiratory chain (22)