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When GAS7b was expressed and observed in live cells, the GAS7b patches appeared at ruffled membranes (Fig

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The addition of catalase suppressed cancer cell death and confirmed the important role of hydrogen peroxide in this anticancer mechanism of action involving ascorbate (Fig

We propose that chronic exposure to a particular suite of environmental and genetic factors elicits a trajectory of impaired mitochondrial biology that maximally impacts subsets of mitotypes abundant in the substantia nigra, striatum, and cerebral cortex, which eventually surfaces as the hallmark features of PD