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In addition, pathways involving the cerebrospinal fluid (CSF), vasculature, and lymphatic system have been implicated in transporting molecules from the nasal cavity to the CNS [8]

IL-1, which we found to be increased in those with LC, has been reported to promote PM through sustained proliferation and differentiation of hematopoietic stem cells (74), driven by persistent antigen or tissue injury

The count data were filtered to remove genes with low expression, transformed using the variance stabilizing transformation from the DESeq2 package (51), and then batch corrected using ComBat (52)

Glucose-6-phosphate, the first product of glycolysis, can also be converted to glucose-1-phosphate by phosphoglucomutase (PGM) for glycogen synthesis and NRF2 activates the expression of PGM5, 1,4-alpha-glucan branching enzyme 1 (GBE1), phosphorylase kinase regulatory subunit alpha 1 (PHKA1), and glucosidase alpha, acid (GAA) involved in glycogen metabolism [35,77,84]

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