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[53] studied the potential role of inflammatory, metabolic, liver damage, and iron metabolism mediators on the inverse association between HCC risk and coffee consumption, as suggested by the reduction in IL-6 levels, a biomarker of inflammation and innate immunity, together with reduced hepatocellular and cholestatic damage biomarkers, i.e., GLDH (glutamate dehydrogenase), ALT (alanine aminotransferase), AST (aspartate aminotransferase), GGT (-glutamyl transferase), and bilirubin
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[DOI] [PubMed] [Google Scholar] 58.Chen G, Han Z, Feng D, Chen Y, Chen L, Wu H, et al
Further research is necessary to test whether a combination of these genetic polymorphisms alters intracellular ROS accumulation to explain the molecular basis for the genegene interactions

doi: 10.1016/j.clindermatol.2021.05.010 42 DosedlMJirkovskEMackovKKrmovLKJavorskLPourovJet al
