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These changes in intracellular GSH levels affect key biological processes, including signal transduction, cell survival, proliferation (167) and various forms of cell death (168,169)
J Appl Physiol 1993, 75: 24192424
Beyond gastrointestinal symptoms, other documented adverse effects include injection site reactions, fatigue, headache, and dizziness
It may also help limit the damage from fatty liver disease
In mHtt-Q74expressing astrocytes, however, this pathway is blocked because mHtt-Q74 co-localizes with TPC2, suggesting a physical interaction that disrupts channel function and lysosomal Ca 2+ signalling
