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Antioxidant and anti-inflammatory agents play a crucial role in protecting ovarian tissue from chemotherapy-induced damage by reducing oxidative stress, inflammation, and apoptosis 15,16

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Exogenous LCACs affect multiple proteins and mechanisms of cardiac ECC, many of which are differentially expressed between animal models and/or function with a divergent ionic stoichiometry ( 2+ propagation, membrane distribution, and re-entry susceptibility when compared to ventricular myocardium ( 2+ -handling protein expression can even be differentially affected in type 2 diabetes (Yamada et al., 2000), is that exogenous LCAC effects are more correctly estimated by determining the LCAC to protein or membrane mole ratios instead of utilizing absolute LCAC concentrations

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