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CAR-M in AID is early and largely preclinical, whereas CAR-T therapies are more mature and have been explored across several AIDs including rheumatoid arthritis (RA), SLE and Sjgrens syndrome (SS) ( 2 CAR-T cell engineering 2.1 CAR-T cell manufacturing and structural design Ex vivo CAR-T production comprises five stages with rigorous quality controls to ensure consistency and safety ( Figure 1A

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Although much of the research has focused on larger peptides and growth factors [25, 26], smaller peptides, particularly tripeptides composed of only three amino acids, are now gaining attention for their efficiency