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Nonetheless, the high-fat phenotype can be suppressed by the inactivation of daf-16 , which suggests that the increased fat synthesis is dependent on the inappropriate activation of daf-16 /FoxO
Thus, different Bifidobacteria and Lactobacilli strains have been demonstrated to extend nematode lifespan, mainly through modulations in the p-38 mitogen-activated protein kinases (p38-MAPK) signalling pathway [103]
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