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Recently, a transgenic mouse model overexpressing a dominant negative version of SARM1 in neurons showed a significant delay in axon degeneration and hints at the promising effect of gene therapy or small molecules targeting SARM1 for treating neuropathies 149

Hydroxocobalamin injections are recommended by NICE for treating B12 deficiency caused by pernicious anaemia or malabsorption

Lifestyle Choices You are also significantly more likely to suffer from B12 deficiency if you practice a vegan diet and lifestyle

Coombes BK, et al

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Tirzepatide's efficacy is blunted in the presence of ultra-processed, hyper-palatable foods that override satiety signaling