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ROS, previously considered mere byproducts of cellular respiration, are oxygen-containing molecules with high reactivity

Prognosis A long-term follow up study of 28 patients with glutathione synthetase deficiency has showed that the factors most predictive of survival and long-term outcome are early diagnosis, correction of acidosis and early supplementation with vitamin C and vitamin E [19]

Kantrowitz JT, Javitt DC

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doi: 10.1016/S0140-6736(23)01419-8 11 BlauwendraatC.HeilbronK.VallergaC

Consistent with these findings, ApoE / mice lacking the FPR2 receptor develop exaggerated aortic dilation following Ang II infusion, accompanied by increased MMP9 expression, reduced collagen deposition, elastic fiber fragmentation, and abnormal infiltration of neutrophils and macrophages [136]