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Proof-of-concept studies with fluorescent and confocal microscopy studies highlighted that the brain-targeted PLGA nanoparticles were able to cross the BBB and accumulated in neuronal cells, thus showing a promising brain drug delivery system

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In 2004, Chan et al., were the first to confirm that stem cells were present in human endometrium (74)

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Abdominal pain and discomfort Abdominal pain was reported in clinical trials at rates modestly above placebo

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