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538 Aged astrocytes indeed express fewer glutamate transporters, resulting in age-dependent decreases in glutamate clearance
The chloride is located in a hydrophobic pocket interacting with I131 C1, V127 C1 and W222 C
Thus, even under reducing cellular conditions, GRXS12 and GRXC5 seem to be glutathionylated, or, alternatively, they become readily glutathionylated in the extract
This phenomenon is known as the Warburg effect or aerobic glycolysis (114)
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doi: 10.1186/s12954-019-0351-1 33 FuX.DongB.TianY.LefebvreP.MengZ.WangX.et al
