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Several reasons may explain the observation that the mean treatment difference was 12.5% in STEP 1 and 8.7% in SELECT

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At least three independent replicates were performed for all experiments with different RNA samples

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Potential therapeutic effects (based on animal and early human data): Enhances tendon, ligament, and muscle repair Promotes angiogenesis (formation of new blood vessels) Reduces inflammation and oxidative stress Protects gut mucosa and may aid in GI disorders (ulcers, leaky gut) May support neurological recovery and joint health Modulates nitric oxide and dopamine/serotonin pathways (possible mood, focus benefits) (Note: Most data are from preclinical studies

These results suggest the potential crucial role of DMF, as an apremilast, in the treatment of patients with psoriasis with concurrent metabolic comorbidities, which are probably the largest part