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It is known that glutamate and D-serine excite synaptic transmission

Fe-doped and doxorubicin loaded HA@Cu 2-X S-PEG (PHCN) nanomaterials were designed as targeted Fe-PHCN@DOX nano-reactors to maximize the effect of ICD to promote antigen presentation thereby stimulating T cell activation, in addition, Fe-PHCN@DOX can reprogram M2 TAMs into M1 TAMs by alleviating tumor hypoxia, at the same time T cell activation is promoted through blockade of the PD-1/PD-L1 immunosuppressive pathway by anti-PD-L1 nanoantibodies thereby achieving effective antitumor effects (226)

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H.LuoH.ZhengZ.QiaoQ.WangL.et al (2020)

The expression profile of genes monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor (TNF), tumor necrosis factor receptor type 1 (TNFR1), transforming growth factor-beta-1 (TGF1), collagen type I alpha 1 chain (Col1,) actin alpha 2 smooth muscle (SMA), tissue inhibitor of metalloproteinases 1 (Timp1), and haptoglobin (Hp) associated with non-alcoholic fatty liver disease (NAFLD) were elevated in the livers of mice fed an HFD for 16 weeks compared with those from mice fed the control diet (Fig