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Research indicates that polyphenols and exercise independently reduce circulating (plasma) pro-inflammatory cytokines such as IL-1 and TNF- while also modulating brain-derived neuroinflammatory markers (e.g., microglial activation and astrocytic response in hippocampal tissue), contributing to improved cognitive and mood-related outcomes [238, 239]

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doi: 10.1002/sscp.202170016 71 NelsonKMDahlinJLBissonJGrahamJPauliGFWaltersMA