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Journal of Bone and Mineral Research, 2007

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"People who really believe that that's the power of placebo." B12 has me like —@katyperry As a geriatrician at Mount Sinai Hospital in Toronto, Sinha said he commonly tests for B12 levels in patients "when we're assessing a person for dementia or a person with balance issues." Otherwise he said it's ineffective to take B12 supplements to prevent deficiency and there are even potential risks of over-doing it

Unknown long-term effects : There is no long-term safety data for either compound used individually in the general population, let alone in combination