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Whereas low or absent caspase 8 expression would disable the capacity to induce extrinsic apoptosis, absence of caspase 8 selectively allows for necroptosis, a non-apoptotic form of cell death driven by receptor-interacting kinase 1 (RIPK1) and RIPK3 17,18,19

J Dermatol 44(8):863872 Zhang J-Z, Cavet ME, VanDerMeid KR, Salvador-Silva M, Lpez FJ, Ward KW (2009) BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells

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