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However, when the autoantibodies cross the barrier and bind to gangliosides of neural tissue, they can activate complement cascades and the resident macrophages by their FcIII receptors inducing cytokine production and inflammation within the nerve tissue
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D., Fang, Y

Vivarelli et al., 2021)

This, in turn, activates the PKA-Smad1/5/8 signaling cascade, ultimately upregulating hepcidin transcription (63)

No compound, however promising the rat data, works optimally in that terrain
