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Its a rule of thumb, not a law of physics there are exceptions but as a first-pass filter for will this absorb from the gut, it holds up well

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Serum Metabolome and Targeted Bile Acid Profiling Reveals Potential Novel Biomarkers for Drug-Induced Liver Injury

Rhonda Patrick: Hemlock, exactly

I guess that's because usually there aren't any - even the acne only affects a very few people
