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PMID: 327 TufailMCuiJWuC

But it was only after the development of solid-phase synthesis processes that the use of peptides for non-therapeutic applications became popular

Cystine depletion can induce ferroptosis

Gradual dissolution of NCs within tumor tissue releases Fe 2+ /Fe 3+ and Cu 2+ , which react with AS to generate carbon-centered radicals (C), amplify oxidative stress, deplete GSH, and down-regulate GPX4 and FDX1, thereby triggering ferroptosis and cuproptosis

This requires specialized fermentation, encapsulation, and cold-chain logistics, which greatly increase production costs compared to traditional probiotics