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PMID: 24518091

Animal testing and alternative approaches for the human health risk assessment under the proposed new European chemicals regulation

The growth of bone, like that of other tissues, results from an increase in cell number, cell size, and extracellular ground substance

However, under oxidative stress or pathological conditions like AGEs (72), Nrf2 is activated and translocated to the nucleus, initiating the expression of antioxidant genes such as GPX4, which are essential for reducing lipid peroxidation and delaying ferroptosis (73)

Targeting the epigenetic regulation of antitumour immunity

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