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This overabundance of free radicals is a major contributor to many diseases, including heart disease and cancer, and it also plays a significant role in age-related changes and illnesses

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239,240 This activation increases the expression of proinflammatory cytokines and adhesion molecules, contributing to oxidative stress, inflammation, and vascular dysfunction

And while some companies, such as Lilly, are testing their analogs as stand-alone therapies, others, including Novo Nordisk, are combining them with GLP-1s

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