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It is possible that a metal ion can bind tightly but not induce the allosteric conformational change, as has been observed for some metal sensor proteins [149]

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[PubMed] [Google Scholar] 13.Ueland PM, Refsum H, Stabler SP, et al

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Medically, a muscle spasm is an involuntary, forceful muscle contraction that is sudden, potentially painful, and can temporarily impair muscle function

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They represent rescue treatment for breakthrough symptoms rather than management strategy

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Curr Biol

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