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In addition, the authors observed that in MSA, patient-derived neurons without a COQ2 mutation also showed some decrease in mitochondrial respiratory functions, suggesting the potential use of supplementation even in this sort of patient [112]
FOXOs are well studied in aging and tissue homeostasis as targets of Insulin/IGF signaling and as regulators of Reactive Oxygen Species(de Keizer et al., 2011
We would also suggest the inclusion of a pediatric population
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