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Huang J, Kang D, Zhang F, Yang Y, Liu C, Xiao J et al (2022) Probiotics plus dietary fiber supplements attenuate olanzapine-induced weight gain in drug-naive first-episode schizophrenia patients: two randomized clinical trials

Previous studies have also reported decreased PON1 activity in patients with active or advanced sarcoidosis ( Reduced PON1 activity has been described in a wide range of inflammatory and oxidative-stressrelated conditions, including atherosclerotic cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, rheumatoid arthritis, and other autoimmune disorders

N-acetylcysteine (NAC) is often recommended to enhance glutathione production because it is a source of cysteine [42]

References were thoroughly reviewed for quality and additional primary data

First of all, the majority of the included researchers did not use the allocation concealment and blind method, which could cause bias in both selection and implementation

This dysfunction results in the loss of immune tolerance to microbiota, making the organism susceptible to attacks by various antigens from the lumen, primarily bacteria and their products such as lipopolysaccharide (LPS) (Pasternak et al., 2011)