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Another limitation to the study is the use of subjective and informant-based instruments (SRS, ABC, SEC, CGI) due to the lack of reliable and readily available objective or performance-based instruments to measure the clinical severity of ASD and treatment outcomes

The biggest known risks are retatrutide-driven GI side effects (nausea 38-43%, diarrhea 33-35%) and dysesthesia - an unusual skin tingling or burning sensation at higher doses

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