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These compounds have been investigated in combination for their complementary and mechanistically distinct receptor pathway interactions, with research examining their combined effects on hypothalamic energy substrate regulation and pancreatic hormone secretion dynamics

Chiva-Blanch G, Urpi-Sarda M, Ros E, Valderas-Martinez P, Casas R, Arranz S,

Pancreatitis : although not confirmed as a direct causal relationship, a potential signal has been observed with this drug class

doi: 10.1007/s10989-022-10427-9

This imbalance is deliberate