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Perfluorooctanesulfonate mediates renal tubular cell apoptosis through PPARgamma inactivation

Mol Syst Biol (2017) 13(9):942

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Phosphorylated IR substrate proteins interact with phosphatidylinositol 3-kinase (PI3K), which then catalyzes the formation of phosphatidylinositol (3,4)-bisphosphate (PIP2) to phosphatidylinositol (3,4,5)-trisphosphate (PIP3) [64]