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thus, they are named T cell engager (TCE) bispecific antibodies

Currently, an ongoing phase III, multicenter, randomized, sham-controlled, double-blind trial is evaluating AT-04s efficacy and safety for endometriosis-related pain (dysmenorrhea, dyspareunia, chronic pelvic pain), with the primary outcome being the change in Numeric Rating Scale score at 16 weeks ( 4.5 Disease heterogeneity and subtype-specific therapeutic strategies Endometriosis exhibits significant clinical and biological heterogeneity, encompassing diverse anatomical subtypessuperficial peritoneal endometriosis (SPE), ovarian endometriomas (OMA), and deep infiltrating endometriosis (DIE)each with distinct pathophysiological features, symptom profiles, and fertility implications ( Table 1 )

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[DOI] [PubMed] [Google Scholar] Kaur C, Rathnasamy G, Ling EA (2016) The choroid plexus in healthy and diseased brain

A., Sacchetti P

The resting state of NLRP3 is regulated by palmitoylation at Cys130, catalyzed by DHHC1, DHHC3, DHHC5, and DHHC7