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Research has shown that the accumulated 25-HC in lysosomes competes with cholesterol for binding to GPR155, inhibiting the kinase mTORC1, which leads to the activation of AMPK and metabolic reprogramming

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172 The Src family kinase Lyn subsequently acts downstream of the BCR to trigger a signaling cascade, leading to full B cell activation

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1974 The Suma Indians of Northern Chihuahua and Western Texas