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Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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10.1016/j.ccell.2015.10.012 41 GamrekelashviliJ.GretenT

About this article Cite this article Tuan, H.T., Ngoc, N.A., Ai, L.D

CDC data show that 38% of U.S