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These processes contribute to severe liver disease in Wilson disease patients, which may progress to acute liver failure and life-threatening outcomes, occasionally necessitating liver transplantation when conventional drug therapy fails

2002;359:211218 Olynyk JK, Cullen DJ, Aquilia S, Rossi E, Summerville L, Powell LW

Senolytic and senomorphic therapies have garnered significant interest as potential methods to promote healthy aging by either eliminating senescent cells or modifying their detrimental secretions.35 These medications represent a compelling domain in gerontology, aiming to restore tissue equilibrium, enhance organ functionality, and mitigate the impact of age-associated ailments.36 In greater detail, cellular senescence confers physiological benefits under specific conditions such as embryonic development, where transient senescence aids tissue patterning

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A trafficking pathway for anthocyanins overlaps with the endoplasmic reticulum-to-vacuole protein-sorting route in Arabidopsis and contributes to the formation of vacuolar inclusions