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Though many immunotherapeutic agents targeting CTLA4 or the PD1/PD-L1 axis have been launched into the clinics for cancer treatment, accumulating clinical evidence has suggested that anti-CTLA4 and anti-PD1 are largely futile in eradicating secondary tumors and extending the lifespan of metastatic cancer patients, due to inherent or acquired drug resistance [303]

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Crystal structure of human MTH1 and the 8-oxo-dGMP product complex
