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Nutrients 13:2660

These reports likely reflect reduced oxidative burden on mitochondrial function rather than direct stimulant activity

Emerging evidence suggests that a cocktail approach, that is, incorporating not only senolytics and senomorphics but also other therapeutic modalities, such as antioxidants, immune modulators, or metabolic enhancers may have a compounded effect in promoting healthy aging.261 Future clinical trials should explore these combination strategies, testing them in diverse age-related diseases to understand the potential for synergy and minimizing possible negative interactions between therapies

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Thus, it is possible that IF causes a negative effect on bone health via a reduction in energy intake and accompanying weight loss