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Nature 414(6865):813820

Receptor activation promotes regulatory T-cell (Treg) differentiation and activity, increases the production of anti-inflammatory cytokines such as interleukin-18 (IL-18), and helps maintain the Th17/Treg balance, thereby attenuating the pro-inflammatory responses characteristic of active IBD [17, 18]

doi: 10.1080/10715760600592962

doi: 10.1111/jdv.14987 30

[PUBMED Abstract] Biondi A, Schrappe M, De Lorenzo P, et al.: Imatinib after induction for treatment of children and adolescents with Philadelphia-chromosome-positive acute lymphoblastic leukaemia (EsPhALL): a randomised, open-label, intergroup study

It is also linked to lower glucagon release after meals, which can improve glycemic stability