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While early activation may serve a protective role by clearing cellular debris, prolonged or excessive activation leads to a shift in phenotype, marked by altered expression of core markers, including the upregulation of inflammatory genes and downregulation of homeostatic functions, which plays a critical role in disease progression and therapeutic targeting (Paolicelli et al., 2022)

doi: 10.1080/07315724.2007.10719624

This was verified with blood safety markers that indicate problems resulting from supplements

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NICEs guideline covers recognising and managing B12 deficiency in adults, including deficiency linked to autoimmune gastritis