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doi: 10.1126/scisignal.aar2124

Ma Q.L., Zuo X., Yang F., et al., Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice, Journal of Biological Chemistry 288, no

After binding to TGR, NADPH donates electrons from its nicotinamide ring to FAD interacting with TGR with its isoalloxazine ring and the nearby C154/C159 redox couple [10,26] for transferring the electrons first to the C596/U597 redox couple on the C-terminal segment of the neighboring subunit, and then to the oxidized Trx or the C28/C31 redox couple of the neighboring monomer to reduce GSSG (S1 Table) [10,26,27]

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No major side effects when taken as recommended

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