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These sensors modulate the expression of cobalt-efflux systems (or in one case a cobalt-requiring enzyme) as cobalt availability increases

10.1089/ars.2021.0102 234 RamliF

doi: 10.1177/1359105317726152 [DOI] [PubMed] [Google Scholar] 544

19 MGST2 trimer structures limit catalysis to one active site at a time, and the biconical central pore modulates hydrophobicity, regulating solvent influx to optimize reaction conditions at the active site

The C-terminal regulatory domain (residues 309397) contains duplicated motifs of mitochondrial targeting signal (MTS) and nuclear localization signal (NLS), providing the molecular basis for its dual localization in the nucleus and mitochondria, respectively (Figure 1A)

Q2: How do I know if I have a B12 deficiency