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Ultrasonographically, only free fluid is detectable (as in lymphedema), while GAG-bound fluid, typical in isolated lipedema, remains invisible 39

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The glutamate produced can either return to the cytoplasm via SLC25A18 and SLC25A22 transporters for the biosynthesis of GSH and non-essential amino acids (e.g., aspartate, alanine, arginine) or undergo complete oxidation or conversion into -KG by mitochondrial transaminases (e.g., GPT2, GOT2) (97, 98)

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