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DOI:10.1016/j.parint.2014.07.004 86

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Transporter-Mediated Nanocarrier Delivery Approach The transporter-mediated nanocarrier delivery strategy is based on the incorporation of transporter substrates on the nanocarrier surface, which bind to the transporter protein on the cellular membrane and trigger the internalization process (80)

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Moreover, dysregulated lipid metabolism networks such as ACSL/SCD also drive EMT and migratory properties, and their pharmacologic inhibition selectively impairs CRC cell viability, further broadening the landscape of metabolic vulnerabilities in metastatic CRC [96]

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