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GLS in the mitochondria catalyzes the breakdown of glutamine to produce glutamate and ammonia (Van Den Heuvel et al., 2012
Excessive production of O- can inhibit glyceraldehyde-3-phosphate dehydrogenase, which is an important enzyme in the glycolytic pathway
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Finally found this
Moreover, Jiang et al
Wang HL, Chou AH, Wu AS, et al
